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Depo-Provera Lawsuit

Recent research into long-acting injectable contraceptives like Depo-Provera, manufactured by Pfizer, has raised concerns over the drug’s link to an increased risk of brain or spine tumors known as meningiomas.

About the Lawsuit

What Is Depo-Provera?

Depo-Provera is a hormonal contraceptive injection intended to provide long-term birth control for women. Though widely promoted as a convenient and effective form of contraception, troubling side effects and long-term health risks have led to a growing number of lawsuits against the drug’s manufacturer, Pfizer.

A Long-Acting Injectable Contraceptive

Depo-Provera is a brand name for the injectable form of medroxyprogesterone acetate, a synthetic hormone that also goes by the name depot medroxyprogesterone acetate. It is administered as a shot every three months and has been marketed as a safe, long-acting form of birth control. However, serious questions have been raised about the drug’s safety, particularly for long-term users.

Depo-Provera works by suppressing ovulation (stopping the ovaries from releasing an egg), thickening cervical mucus, and thinning the uterine lining to prevent pregnancy. It largely tries to keep sperm from reaching the egg. It has been approved by the FDA for use since the early 1990s, but concerns about its risks have grown significantly in recent years.

Why Is There a Depo-Provera Lawsuit?

The lawsuits surrounding Depo-Provera focus primarily on claims that the drug’s manufacturer failed to adequately warn users about serious risks, including brain tumors or meningiomas. Plaintiffs allege that if they had been properly warned of these risks, they would have chosen a different method of contraception.

In 2004, the FDA required a “black box” warning for Depo-Provera to address the risk of significant bone density loss. However, the warning failed to mention anything regarding the possibility of developing a brain tumor. The FDA warning also states that the medicine shouldn’t be used for longer than two years.

Dangers of Using Depo-Provera

Depo-Provera & Meningiomas

After using Depo-Provera, many women were later diagnosed with meningiomas — tumors of the brain or spine — complications they claim were never adequately disclosed. According to the Mayo Clinic, other reported side effects of Depo-Provera include:

The Legal Claims

The Legal Claims Against Depo-Provera

The core legal issue in these cases is failure to warn. Drug manufacturers have a duty to inform consumers and healthcare providers of all known and reasonably knowable risks. When companies prioritize profits over patient safety, the consequences can be devastating. Claimants may be eligible to file lawsuits seeking compensation for:
In cases involving egregious misconduct, punitive damages may also be pursued.

Is There a Class Action or MDL?

On February 7, 2025, the Judicial Panel on Multidistrict Litigation centralized and transferred the Depo-Provera (Depot Medroxyprogesterone Acetate) Products Liability Litigation, MDL No. 3140, to the Northern District of Florida before Judge M. Casey Rodgers. Constant Legal Group is actively monitoring legal developments and preparing to support individuals harmed by Depo-Provera.

Do I Qualify to File a Lawsuit?

You may qualify if:

Even if your injuries occurred years ago, there may be exceptions depending on when you learned of the link between your health condition and the drug. Our legal team can help evaluate your case.

Background

A History of Depo-Provera Lawsuits and Cases

1990s–2000s

Bone health issues emerge

As Depo-Provera (medroxyprogesterone acetate, or “DMPA”) became widely used, long-term users began reporting significant bone mineral density loss, osteoporosis, and even fractures.

2004

FDA “black box” warning introduced

A mandatory warning was added to highlight the risks of prolonged bone loss, particularly after two years of continuous use.

2008

Cassandra Colville vs. Pharmacia & Upjohn

A U.S. lawsuit focused on osteoporosis claims brought by a former Depo-Provera user.

2008–2021

Canada class action

A class action in Canada alleged Pfizer misrepresented bone-loss risks. In 2021, Pfizer settled, paying approximately CAD 1.9 million to the class and CAD 262,500 to insurers.

February 7, 2025

MDL No. 3140 centralized

The Judicial Panel on Multidistrict Litigation centralized the Depo-Provera Products Liability Litigation in the Northern District of Florida before Judge M. Casey Rodgers.

Frequently Asked Questions

About Depo-Provera Lawsuits

While effective for contraception, Depo-Provera has been linked to serious side effects like irreversible bone loss, depression, and fertility issues, especially with long-term use.

Yes, in 2004 the FDA added a black box warning to Depo-Provera’s label regarding the risk of significant and potentially irreversible bone density loss.

Lawsuits allege that the manufacturer failed to adequately warn patients about the risks, leaving many women with lasting health complications they didn’t expect.

Contact a qualified defective drug attorney at Constant Legal Group who can evaluate your case and guide you through the legal process with no upfront cost.

Free Case Review

Get Started on a Depo-Provera Lawsuit Today

If you believe you’ve suffered harm after using Depo-Provera, don’t wait. Legal deadlines apply, and the sooner you act, the better positioned you are to build a strong case.

Reach out to Constant Legal Group today for a free, confidential case evaluation. Our compassionate and experienced attorneys are here to help you understand your rights, pursue justice, and recover the compensation you deserve.

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